Trimethobenzamide HCl in the treatment of nausea and vomiting associated with antineoplastic chemotherapy.

Article Details

Citation

Hurley JD, Eshelman FN

Trimethobenzamide HCl in the treatment of nausea and vomiting associated with antineoplastic chemotherapy.

J Clin Pharmacol. 1980 May-Jun;20(5-6 Pt 1):352-6.

PubMed ID
7400373 [ View in PubMed
]
Abstract

Fifty-five patients undergoing chemotherapy for various neoplastic processes were treated with trimethobenzamide or placebo to control nausea and vomiting. Trimethobenzamide was shown to be significantly better than placebo in relieving periodic and total nausea over the 48-hour study. Vomiting incidence was also reduced in the group receiving trimethobenzamide. Differences were noted in the degree of emetic stimulus associated with different chemotherapeutic regimens. No side effects attributable to trimethobenzamide were recorded.

DrugBank Data that Cites this Article

Drugs