A new family of 2-hydroxyacid dehydrogenases.

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Grant GA

A new family of 2-hydroxyacid dehydrogenases.

Biochem Biophys Res Commun. 1989 Dec 29;165(3):1371-4.

PubMed ID
2692566 [ View in PubMed
]
Abstract

The NADH-dependent hydroxypyruvate reductase from cucumber and the pdxB gene product of E. coli display significant homology to E. coli D-3-phosphoglycerate dehydrogenase. In contrast, these proteins do not display much similarity with other oxidoreductases or with other 2-hydroxyacid dehydrogenases in particular. On the basis of their relatedness and the structure of their substrates, these three enzymes constitute a new family of 2-hydroxyacid dehydrogenases distinct from malate and lactate dehydrogenase.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
NADHD-3-phosphoglycerate dehydrogenaseProteinHumans
Unknown
Not AvailableDetails