Evaluation of vitamin K3 feed additive for prevention of sweet clover disease.

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Casper HH, Alstad AD, Tacke DB, Johnson LJ, Lloyd WE

Evaluation of vitamin K3 feed additive for prevention of sweet clover disease.

J Vet Diagn Invest. 1989 Apr;1(2):116-9.

PubMed ID

2484931 [ View in PubMed

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Abstract

Sweet clover poisoning in cattle is caused by an anticoagulant (dicumarol) that is formed in moldy sweet clover hay. Previous experiments with vitamin K3 and vitamin K1 in therapy trials indicated that vitamin K1 was effective in reducing prothrombin times but vitamin K3 was not. As a possible alternative in the use of toxic sweet clover hays, vitamin K3 was evaluated to see if it would prevent hemorrhagic crises when fed to cattle consuming toxic sweet clover hay. Vitamin K3 levels of 0, 0.45, 4.5, 11, and 45 mg/kg body weight/day were fed to 173-235-kg steers consuming toxic (40-50 ppm dicumarol) sweet clover. The 45-mg K3/kg/day supplement was not palatable and had to be discontinued. The 0.45, 4.5, and 11-mg K3/kg/day supplements did not significantly reduce the prothrombin times as compared to the 0-mg K3/kg/day group.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Menadione	Prothrombin	Protein	Humans	Unknown	Activator	Details