Metabolic fate of cyanocobalamin taken up by Spirometra mansonoides spargana.

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Tkachuck RD, Weinstein PP, Mueller JF

Metabolic fate of cyanocobalamin taken up by Spirometra mansonoides spargana.

J Parasitol. 1977 Aug;63(4):694-700.

PubMed ID

18565 [ View in PubMed

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Abstract

Analysis of tissue from Spirometra mansonoides spargana has shown that cyanocobalamin (vitamin B12) is metabolized to adenosylcobalamin and hydroxocobalamin. No methylcobalamin was detected. When the tissues were examined for enzymes which are known to utilize coenzyme forms of vitamin B12, only methylmalonyl CoA mutase, which requires adenosylcobalamin was found. The enzyme, tetrahydropteroylglutamate methyltransferase, which requires methylcobalamin as a cofactor, was not detected. A sizable portion of the cyanocobalamin taken up was bound to ammonium sulfate-precipitable material, suggesting that the binding substance is a protein. Vitamin B12 taken up by spargana was found to be released in vivo with a biological half-life of about 7 weeks.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Hydroxocobalamin	Methionine synthase	Protein	Humans	Yes	Cofactor	Details
Hydroxocobalamin	Methylmalonyl-CoA mutase, mitochondrial	Protein	Humans	Yes	Cofactor	Details