Comparison of guanadrel and guanethidine efficacy and side effects.

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Malinow SH

Comparison of guanadrel and guanethidine efficacy and side effects.

Clin Ther. 1983;5(3):284-9.

PubMed ID

6850722 [ View in PubMed

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Abstract

Eighteen patients with essential hypertension uncontrolled by hydrochlorothiazide alone were randomly assigned to receive additional therapy with either guanadrel sulfate or guanethidine sulfate. The frequencies of morning orthostatic faintness, other orthostatic faintness, and diarrhea were twice as high in eight patients treated with guanethidine as in ten patients treated with guanadrel in a six-month comparison. The two drugs reduced blood pressure about equally well. In light of the efficacy without severe side effects, guanadrel may be an agent for step II therapy of hypertension.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Guanadrel	Sodium-dependent noradrenaline transporter	Protein	Humans	Yes	Partial agonist	Details