Phosphoinositide 3-kinase delta (PI3Kdelta) in leukocyte signaling and function.

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Citation

Fung-Leung WP

Phosphoinositide 3-kinase delta (PI3Kdelta) in leukocyte signaling and function.

Cell Signal. 2011 Apr;23(4):603-8. doi: 10.1016/j.cellsig.2010.10.002. Epub 2010 Oct 16.

PubMed ID
20940048 [ View in PubMed
]
Abstract

PI3Kdelta is a lipid kinase of the PI3K class IA family involved in early signaling events of leukocytes responding to a wide variety of stimuli. The leukocyte specificity of PI3Kdelta is defined by its expression, whereas its signaling function is via the production of phosphoinositide 3,4,5-triphosphates at the proximity of activated receptors for recruiting other signaling molecules. The importance of PI3Kdelta in B cell development and function is most apparent, and its role in other leukocyte cell types can be easily demonstrated as well. PI3Kdelta participates in the development, activation and migration of T cells and NK cells. The role of PI3Kdelta in myeloid cell activities, such as inflammation driven cell infiltration, neutrophil oxidative burst, immune complex mediated macrophage activation, as well as mast cell maturation and degranulation, has been well illustrated in various studies. As a result of the broad effects of PI3Kdelta in leukocyte functions, the disruption of PI3Kdelta expression or activity leads to decreased inflammatory and immune responses in vivo. The protective role of PI3Kdelta inactivation in animal models of arthritis, asthma or obstructive respiratory diseases has been demonstrated. These findings suggest the potential efficacy achievable with PI3Kdelta inhibitors in the treatment of autoimmune and respiratory diseases.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformO00329Details