Brain and plasma kinetics of the opioid 11C-hydromorphone in two macaque species.

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Hartvig P, Neil A, Terenius L, Antoni G, Rimland A, Ulin J, Langstrom B

Brain and plasma kinetics of the opioid 11C-hydromorphone in two macaque species.

Pharmacol Toxicol. 1989 Sep;65(3):214-6.

PubMed ID

2478994 [ View in PubMed

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Abstract

The regional brain kinetics of the opioid receptor agonist, hydromorphone, labelled with 11C, were studied with positron emission tomography in two Macaque species. Rhesus and Cynomolgus monkeys. The plasma kinetics of 11C-hydromorphone was simultaneously determined. Rapid plasma elimination was obvious in both monkey species. Brain radioactivity was generally low in both, but 1.4 times higher in the Rhesus than in the Cynomolgus monkey brain. This observation might explain the more rapid development of tolerance in the Rhesus monkey.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Hydromorphone	Delta-type opioid receptor	Protein	Humans	Yes	Partial agonist	Details