Two faces of protein kinase Cdelta: the contrasting roles of PKCdelta in cell survival and cell death.
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Basu A, Pal D
Two faces of protein kinase Cdelta: the contrasting roles of PKCdelta in cell survival and cell death.
ScientificWorldJournal. 2010 Nov 16;10:2272-84. doi: 10.1100/tsw.2010.214.
- PubMed ID
- 21103796 [ View in PubMed]
- Abstract
Protein kinase Cdelta (PKCdelta) is a member of the PKC family that plays a critical role in the regulation of various cellular processes, including cell proliferation, cell death, and tumor promotion. Since the identification that PKCdelta is a substrate for caspase-3, there has been overwhelming literature that linked PKCdelta with proapoptotic signaling. While PKCdelta generally functions as a proapoptotic protein during DNA damage-induced apoptosis, it can act as an antiapoptotic protein during receptor-initiated cell death. PKCdelta has also been implicated in tumor suppression as well as survival of several cancers. The function of PKC-delta depends on various factors, including its localization, tyrosine phosphorylation, and the presence of other pro- and antiapoptoic signaling molecules. This review discusses the current literature on the contrasting roles of PKCdelta in cell survival and cell death.