Two faces of protein kinase Cdelta: the contrasting roles of PKCdelta in cell survival and cell death.

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Citation

Basu A, Pal D

Two faces of protein kinase Cdelta: the contrasting roles of PKCdelta in cell survival and cell death.

ScientificWorldJournal. 2010 Nov 16;10:2272-84. doi: 10.1100/tsw.2010.214.

PubMed ID
21103796 [ View in PubMed
]
Abstract

Protein kinase Cdelta (PKCdelta) is a member of the PKC family that plays a critical role in the regulation of various cellular processes, including cell proliferation, cell death, and tumor promotion. Since the identification that PKCdelta is a substrate for caspase-3, there has been overwhelming literature that linked PKCdelta with proapoptotic signaling. While PKCdelta generally functions as a proapoptotic protein during DNA damage-induced apoptosis, it can act as an antiapoptotic protein during receptor-initiated cell death. PKCdelta has also been implicated in tumor suppression as well as survival of several cancers. The function of PKC-delta depends on various factors, including its localization, tyrosine phosphorylation, and the presence of other pro- and antiapoptoic signaling molecules. This review discusses the current literature on the contrasting roles of PKCdelta in cell survival and cell death.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Protein kinase C delta typeQ05655Details