Structure of human cytidine deaminase bound to a potent inhibitor.
Article Details
- CitationCopy to clipboard
Chung SJ, Fromme JC, Verdine GL
Structure of human cytidine deaminase bound to a potent inhibitor.
J Med Chem. 2005 Feb 10;48(3):658-60.
- PubMed ID
- 15689149 [ View in PubMed]
- Abstract
Human cytidine deaminase (CDA) is an enzyme prominent for its role in catalyzing metabolic processing of nucleoside-type anticancer and antiviral agents. It is thus a promising target for the development of small molecule therapeutic adjuvants. We report the first crystal structure of human CDA as a complex with a tight-binding inhibitor, diazepinone riboside 1. The structure reveals that inhibitor 1 is able to establish a canonical pi/pi-interaction with a key active site residue, Phe 137.