Serotonin2 (5-HT2) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) inhibits chlorpromazine- and haloperidol-induced hypothermia in mice.

Article Details

Citation

Yamada J, Sugimoto Y, Horisaka K

Serotonin2 (5-HT2) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) inhibits chlorpromazine- and haloperidol-induced hypothermia in mice.

Biol Pharm Bull. 1995 Nov;18(11):1580-3.

PubMed ID
8593484 [ View in PubMed
]
Abstract

Chlorpromazine- and haloperidol-induced hypothermia were examined in mice. The alpha 1 receptor agonist phenylephrine partially antagonized the hypothermia, while the dopamine D2 receptor agonist apomorphine did not inhibit it. The central serotonin2 (5-HT2) receptor agonist I-2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) strongly inhibited the chlorpromazine- and haloperidol-induced hypothermia. Both drugs at doses which can elicit hypothermia antagonized head twitch responses mediated by the central 5-HT2 receptor. These results suggest that the chlorpromazine- and haloperidol-induced hypothermia may be mediated by the blockade of the central 5-HT2 receptor.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Acepromazine5-hydroxytryptamine receptor 2AProteinHumans
Yes
Antagonist
Details
Chlorpromazine5-hydroxytryptamine receptor 2AProteinHumans
Yes
Antagonist
Details
Pipotiazine5-hydroxytryptamine receptor 2AProteinHumans
Yes
Antagonist
Details