Serotonin2 (5-HT2) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) inhibits chlorpromazine- and haloperidol-induced hypothermia in mice.
Article Details
- CitationCopy to clipboard
Yamada J, Sugimoto Y, Horisaka K
Serotonin2 (5-HT2) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) inhibits chlorpromazine- and haloperidol-induced hypothermia in mice.
Biol Pharm Bull. 1995 Nov;18(11):1580-3.
- PubMed ID
- 8593484 [ View in PubMed]
- Abstract
Chlorpromazine- and haloperidol-induced hypothermia were examined in mice. The alpha 1 receptor agonist phenylephrine partially antagonized the hypothermia, while the dopamine D2 receptor agonist apomorphine did not inhibit it. The central serotonin2 (5-HT2) receptor agonist I-2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) strongly inhibited the chlorpromazine- and haloperidol-induced hypothermia. Both drugs at doses which can elicit hypothermia antagonized head twitch responses mediated by the central 5-HT2 receptor. These results suggest that the chlorpromazine- and haloperidol-induced hypothermia may be mediated by the blockade of the central 5-HT2 receptor.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Acepromazine 5-hydroxytryptamine receptor 2A Protein Humans YesAntagonistDetails Chlorpromazine 5-hydroxytryptamine receptor 2A Protein Humans YesAntagonistDetails Pipotiazine 5-hydroxytryptamine receptor 2A Protein Humans YesAntagonistDetails