Isolation, sequence, and differential expression of a human K7 gene in simple epithelial cells.

Article Details

Citation

Glass C, Fuchs E

Isolation, sequence, and differential expression of a human K7 gene in simple epithelial cells.

J Cell Biol. 1988 Oct;107(4):1337-50.

PubMed ID
2459129 [ View in PubMed
]
Abstract

Simple epithelial cells synthesize a different set of keratins than epidermal cells. In experiments reported in this manuscript, we show that the base level of keratin expression in simple epithelial cells is variable for different cell types, and that, in some simple epithelia, this level can be upregulated by increasing the exposure of cells to retinoids, but not glucocorticoids or estradiol. To elucidate the molecular mechanisms underlying simple epithelial keratin gene regulation, we have isolated and characterized a human gene encoding the simple epithelial keratin K7. By examining the possible regulatory elements of this gene and by investigating the behavior of this gene introduced transiently into simple epithelial cells, we have uncovered a possible basis for the differential expression of epidermal and simple epithelial keratin genes.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Keratin, type II cytoskeletal 7P08729Details