Alitretinoin: in severe chronic hand eczema.
Article Details
- CitationCopy to clipboard
Garnock-Jones KP, Perry CM
Alitretinoin: in severe chronic hand eczema.
Drugs. 2009 Aug 20;69(12):1625-34. doi: 10.2165/11202200-000000000-00000.
- PubMed ID
- 19678713 [ View in PubMed]
- Abstract
Alitretinoin is an endogenous retinoid and acts as a pan-agonist at retinoid receptors, binding with high affinity to both retinoic acid receptors and retinoid X receptors (RXR). Oral alitretinoin once daily is approved for use in patients with severe chronic hand eczema unresponsive to treatment with potent topical corticosteroids. In a large (n = 1032), randomized, double-blind, placebo-controlled, multicentre study (BACH) of up to 24 weeks' duration in adults with severe chronic hand eczema, significantly more patients in the alitretinoin 10 or 30 mg/day groups than in the placebo group responded to treatment with clear/almost clear hands, as assessed by the Physician Global Assessment (PGA) [primary endpoint]. In an extension phase of the BACH study, alitretinoin was effective in patients who relapsed after responding to initial treatment with the drug. Of patients who had responded to initial treatment with alitretinoin 30 mg/day, significantly more alitretinoin 30 mg/day than placebo recipients responded on the PGA with clear/almost clear hands during the extension phase (primary endpoint; 80% vs 8%). Of those who had responded to initial treatment with alitretinoin 10 mg/day, 48% of alitretinoin 10 mg/day and 10% of placebo recipients responded during the extension phase. Alitretinoin was generally well tolerated in clinical trials excluding pregnant women. The most common treatment-emergent adverse events and abnormal laboratory test results were consistent with those previously observed with other oral retinoids and RXR agonists.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Alitretinoin Retinoic acid receptor beta Protein Humans YesAgonistDetails Alitretinoin Retinoic acid receptor gamma Protein Humans YesAgonistDetails Alitretinoin Retinoic acid receptor RXR-alpha Protein Humans YesAgonistDetails Alitretinoin Retinoic acid receptor RXR-beta Protein Humans YesAgonistDetails Alitretinoin Retinoic acid receptor RXR-gamma Protein Humans YesAgonistDetails