Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel.
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Cheng Q, Sedlic F, Pravdic D, Bosnjak ZJ, Kwok WM
Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel.
FEBS Lett. 2011 Jan 21;585(2):328-34. doi: 10.1016/j.febslet.2010.12.008. Epub 2010 Dec 13.
- PubMed ID
- 21156174 [ View in PubMed]
- Abstract
Nitric oxide (NO.) effects on the cardiac mitochondrial voltage-dependent anion channel (VDAC) are unknown. The effects of exogenous NO. on VDAC purified from rat hearts were investigated in this study. When incorporated into lipid bilayers, VDAC was inhibited directly by an NO. donor, PAPA NONOate, in a concentration-dependent biphasic manner. This was prevented by an NO. scavenger, 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide. The effect paralleled that of NO() in delaying the opening of the mitochondrial permeability transition (PT) pore. These biphasic effects on the cardiac VDAC and the mitochondrial PT pore reveal a tandem impact of NO() on the two mitochondrial entities.