Alternative splicing of cyclooxygenase-1 mRNA in the human iris.

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Droge MJ, van Sorge AA, van Haeringen NJ, Quax WJ, Zaagsma J

Alternative splicing of cyclooxygenase-1 mRNA in the human iris.

Ophthalmic Res. 2003 May-Jun;35(3):160-3.

PubMed ID

12711844 [ View in PubMed

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Abstract

In homogenates of the human iris, the nonsteroidal anti-inflammatory drug (NSAID) S(+)flurbiprofen has been reported to inhibit cyclooxygenase-1 (COX-1) 70-fold more potently than in human whole blood. We hypothesized that this difference may be due to alternative splicing of COX-1 mRNA in the human iris or in whole blood. In this study, we have identified a similar COX-1 splice variant (COX-1SV) in both tissues with comparable COX-1/COX-1SV expression ratios. Therefore, we conclude that the difference in IC(50) values of S(+)flurbiprofen towards COX-1 in the human iris and human whole blood is not related to differences in the occurrence of spliced COX-1.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Flurbiprofen	Prostaglandin G/H synthase 1	Protein	Humans	Unknown	Inhibitor	Details