Effect of minaprine on cycloheximide-induced amnesia in mice.

Article Details

Citation

Nabeshima T, Kawashima K, Kameyama T

Effect of minaprine on cycloheximide-induced amnesia in mice.

Eur J Pharmacol. 1989 Oct 10;169(2-3):249-57.

PubMed ID
2530096 [ View in PubMed
]
Abstract

The effects of minaprine on cycloheximide-induced amnesia were investigated in a step-down passive avoidance task in mice. Minaprine significantly improved cycloheximide-induced amnesia. This effect was inhibited by scopolamine, but was potentiated by physostigmine. The anti-amnesic effect of minaprine on the cycloheximide-induced memory impairment was also antagonized by a serotonin (5-HT) releaser, p-chloroamphetamine, and by a 5-HT precursor, 5-hydroxytryptophan, whereas a 5-HT1A-selective agonist, 8-hydroxy-2-(di-n-propylamino)tetralin, was inactive. The memory-improving effect of minaprine on cycloheximide-induced amnesia was potentiated by a selective 5-HT2 antagonist, ritanserin. These results suggest that the beneficial effect of minaprine on cycloheximide-induced amnesia may be related not only to cholinergic but also serotonergic neuronal systems (5-HT2 receptors).

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Minaprine5-hydroxytryptamine receptor 2AProteinHumans
Yes
Antagonist
Details