Effect of minaprine on cycloheximide-induced amnesia in mice.
Article Details
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Nabeshima T, Kawashima K, Kameyama T
Effect of minaprine on cycloheximide-induced amnesia in mice.
Eur J Pharmacol. 1989 Oct 10;169(2-3):249-57.
- PubMed ID
- 2530096 [ View in PubMed]
- Abstract
The effects of minaprine on cycloheximide-induced amnesia were investigated in a step-down passive avoidance task in mice. Minaprine significantly improved cycloheximide-induced amnesia. This effect was inhibited by scopolamine, but was potentiated by physostigmine. The anti-amnesic effect of minaprine on the cycloheximide-induced memory impairment was also antagonized by a serotonin (5-HT) releaser, p-chloroamphetamine, and by a 5-HT precursor, 5-hydroxytryptophan, whereas a 5-HT1A-selective agonist, 8-hydroxy-2-(di-n-propylamino)tetralin, was inactive. The memory-improving effect of minaprine on cycloheximide-induced amnesia was potentiated by a selective 5-HT2 antagonist, ritanserin. These results suggest that the beneficial effect of minaprine on cycloheximide-induced amnesia may be related not only to cholinergic but also serotonergic neuronal systems (5-HT2 receptors).
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Minaprine 5-hydroxytryptamine receptor 2A Protein Humans YesAntagonistDetails