Binding site of loperamide: automated docking of loperamide in human mu- and delta-opioid receptors.
Article Details
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di Bosco AM, Grieco P, Diurno MV, Campiglia P, Novellino E, Mazzoni O
Binding site of loperamide: automated docking of loperamide in human mu- and delta-opioid receptors.
Chem Biol Drug Des. 2008 Apr;71(4):328-35. doi: 10.1111/j.1747-0285.2008.00637.x. Epub 2008 Feb 12.
- PubMed ID
- 18284554 [ View in PubMed]
- Abstract
Loperamide is a piperidine analogue, acting as agonist on peripheral opioid receptors, exhibiting affinity and selectivity for the cloned mu human opioid receptor compared with the delta human opioid receptor. Automatic docking studies of loperamide, using AutoDock, on human mu- and delta-opioid receptors is described. Whilst no meaningful difference was detected concerning the docking of the arylpiperidine moiety, mu/delta selectivity could be explained as a different accommodation of the two phenyl groups in two lipophylic pockets of receptors.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Loperamide Delta-type opioid receptor Protein Humans UnknownAgonistDetails Loperamide Mu-type opioid receptor Protein Humans YesAgonistDetails