Effect of ketotifen on acute gastric lesions and gastric secretion in rats.

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Okabe S, Nakaji S, Tachibana M

Effect of ketotifen on acute gastric lesions and gastric secretion in rats.

Jpn J Pharmacol. 1992 Jun;59(2):251-4.

PubMed ID
1434122 [ View in PubMed
]
Abstract

Ketotifen, a histamine H1-receptor antagonist and mast cell stabilizer, significantly protected the rat gastric mucosa against lesions induced by necrotizing agents, histamine or compound 48/80. The agent significantly inhibited the basal gastric acid secretion, but had little or no effect on the histamine-stimulated secretion. The mucosal protective effect was observed even at a dose that had little or no effect on gastric acid secretion, suggesting that ketotifen exhibits so-called cytoprotective activity.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
KetotifenHistamine H1 receptorProteinHumans
Yes
Antagonist
Details