Tegaserod: a new 5-HT(4) agonist in the treatment of irritable bowel syndrome.

Article Details

Citation

Corsetti M, Tack J

Tegaserod: a new 5-HT(4) agonist in the treatment of irritable bowel syndrome.

Expert Opin Pharmacother. 2002 Aug;3(8):1211-8.

PubMed ID
12150698 [ View in PubMed
]
Abstract

Tegaserod is a selective partial agonist acting on serotonergic type 4 receptors (5-HT(4)). Pharmacodynamic studies indicate that tegaserod is able to stimulate gut propulsion and secretion with a net prokinetic effect. In contrast to other 5-HT(4) agonists endowed with a complex pharmacological profile, tegaserod has a reliable prokinetic activity in the colon. Clinical trials show that tegaserod is effective and safe in the treatment of patients with irritable bowel syndrome. In particular, tegaserod relieves symptoms of abdominal pain, discomfort, abdominal bloating and constipation.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Tegaserod5-hydroxytryptamine receptor 4ProteinHumans
Yes
Antagonist
Partial agonist
Details