Cloning, expression and chromosomal localization of a member of the human cytochrome P450IIC gene sub-family.
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Shephard EA, Phillips IR, Santisteban I, Palmer CN, Povey S
Cloning, expression and chromosomal localization of a member of the human cytochrome P450IIC gene sub-family.
Ann Hum Genet. 1989 Jan;53(Pt 1):23-31.
- PubMed ID
- 2729895 [ View in PubMed]
- Abstract
We have isolated and sequenced a cDNA clone (pB8) that codes for a novel member of the cytochrome P450IIC sub-family of man. Analysis, by Southern blot hybridization, of DNA isolated from a panel of nine independent human-rodent somatic cell hybrids demonstrated that the corresponding gene (CYP2C) is located on human chromosome 10. Northern blot hybridization of RNA isolated from human livers revealed a 10-fold inter-individual variation in the expression of the gene.