On the mode of action of pseudomonic acid: inhibition of protein synthesis in Staphylococcus aureus.

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Hughes J, Mellows G

On the mode of action of pseudomonic acid: inhibition of protein synthesis in Staphylococcus aureus.

J Antibiot (Tokyo). 1978 Apr;31(4):330-5.

PubMed ID

659331 [ View in PubMed

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Abstract

The effect of the antibiotic, pseudomonic acid, on the major metabolic processes in Staphylococcus aureus was studied. The primary effect of low concentrations of the antibiotic, leading to bacteriostasis, is inhibition of protein synthesis. Pseudomonic acid also severely inhibits RNA synthesis which can be prevented by chloramphenicol treatment. DNA and cell wall peptidoglycan synthesis are inhibited to a lesser extent and interference with these processes is considered to be a secondary effect. Oxidative phosphorylation as measured by ATP levels was not inhibited.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Mupirocin	Isoleucine--tRNA ligase	Protein	Staphylococcus aureus	Yes	Inhibitor	Details