Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development.

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Citation

Rosengard AM, Krutzsch HC, Shearn A, Biggs JR, Barker E, Margulies IM, King CR, Liotta LA, Steeg PS

Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development.

Nature. 1989 Nov 9;342(6246):177-80.

PubMed ID
2509941 [ View in PubMed
]
Abstract

Tumour metastasis is the principal cause of death for cancer patients. We have identified the nm23 gene, for which RNA levels are reduced in tumour cells of high metastatic potential. In this report we identify the cytoplasmic and nuclear Nm23 protein, and show that it also is differentially expressed in metastatic tumour cells. We also find that the human Nm23 protein has sequence homology over the entire translated region with a recently described developmentally regulated protein in Drosophila, encoded by the abnormal wing discs (awd) gene. Mutations in awd cause abnormal tissue morphology and necrosis and widespread aberrant differentiation in Drosophila, analogous to changes in malignant progression. The metastatic state may therefore be determined by the loss of genes such as nm23/awd which normally regulate development.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Nucleoside diphosphate kinase AP15531Details