Glutathione-related enzymes contribute to resistance of tumor cells and low toxicity in normal organs to artesunate.

Article Details

Citation
Copy to clipboard

Efferth T, Volm M

Glutathione-related enzymes contribute to resistance of tumor cells and low toxicity in normal organs to artesunate.

In Vivo. 2005 Jan-Feb;19(1):225-32.

PubMed ID
15796179 [ View in PubMed
]
Abstract

The anti-malarial artesunate (ART) also inhibits the growth of cancer cells. The active moiety is an endoperoxide bridge whose cleavage generates reactive oxygen species and free radicals. We analyzed whether glutathione-related enzymes contribute to tumor resistance to ART and to the low toxicity of ART towards normal organs. The microarray-based mRNA expression of dihydrodiol dehydrogenase, gamma-glutamylcysteine synthase (gamma-GCS), glutathione S-transferases GSTM4, GSTT2, GSTZ1, and microsomal glutathione S-transferase MGST3 showed significant relationships (p <0.05) to cellular response to ART in 55 cell lines of the National Cancer Institute, USA. A tendency for correlation (0.05

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
GlutathioneGlutathione S-transferase Mu 4ProteinHumans
Unknown
Not AvailableDetails