New disguises for an old channel: MaxiK channel beta-subunits.
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Orio P, Rojas P, Ferreira G, Latorre R
New disguises for an old channel: MaxiK channel beta-subunits.
News Physiol Sci. 2002 Aug;17:156-61.
- PubMed ID
- 12136044 [ View in PubMed]
- Abstract
Ca(2+)-activated K(+) channels of large conductance (MaxiK or BK channels) control a large variety of physiological processes, including smooth muscle tone, neurosecretion, and hearing. Despite being coded by a single gene (Slowpoke), the diversity of MaxiK channels is great. Regulatory b-subunits, splicing, and metabolic regulation create this diversity fundamental to the adequate function of many tissues.