Focus on levomepromazine.

Article Details

Citation

Green B, Pettit T, Faith L, Seaton K

Focus on levomepromazine.

Curr Med Res Opin. 2004 Dec;20(12):1877-81.

PubMed ID
15701205 [ View in PubMed
]
Abstract

This is a review of the uses of levomepromazine in psychiatry, based upon MEDLINE, PSYCLIT and EMBASE literature searches. The main indications for this drug in psychiatry are schizophrenia and schizoaffective disorder. Levomepromazine's sedative properties particularly fit it to use in psychiatric intensive care. There is also some evidence to suggest it has efficacy in drug-resistant psychosis, although this property of the drug does require further research. In other areas of medicine levomepromazine has been used in: alleviating bronchoconstriction; as a preoperative sedative; in terminal pain control and postoperative analgesia; and in the control of nausea. Some antimycobacterial properties have been recorded. The drug should not be prescribed to patients at high risk of accidental or suicidal overdose.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Methotrimeprazine5-hydroxytryptamine receptor 2AProteinHumans
Unknown
Antagonist
Details
Methotrimeprazine5-hydroxytryptamine receptor 2CProteinHumans
Unknown
Antagonist
Details
MethotrimeprazineAlpha-1A adrenergic receptorProteinHumans
Unknown
Antagonist
Details
MethotrimeprazineAlpha-1B adrenergic receptorProteinHumans
Unknown
Antagonist
Details
MethotrimeprazineAlpha-1D adrenergic receptorProteinHumans
Unknown
Antagonist
Details
MethotrimeprazineAlpha-2A adrenergic receptorProteinHumans
Unknown
Antagonist
Details
MethotrimeprazineAlpha-2B adrenergic receptorProteinHumans
Unknown
Antagonist
Details
MethotrimeprazineAlpha-2C adrenergic receptorProteinHumans
Unknown
Antagonist
Details
MethotrimeprazineDopamine D1 receptorProteinHumans
Unknown
Antagonist
Details
MethotrimeprazineDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
MethotrimeprazineDopamine D3 receptorProteinHumans
Unknown
Antagonist
Details
MethotrimeprazineDopamine D4 receptorProteinHumans
Unknown
Antagonist
Details
MethotrimeprazineDopamine D5 receptorProteinHumans
Unknown
Antagonist
Details