Aspirin and NSAID sensitivity.

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Stevenson DD

Aspirin and NSAID sensitivity.

Immunol Allergy Clin North Am. 2004 Aug;24(3):491-505, vii.

PubMed ID

15242723 [ View in PubMed

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Abstract

Aspirin and the older nonsteroidal anti-inflammatory drugs (NSAIDs) that block cyclo-oxygenase-1 (COX-1) induce asthma attacks in patients with aspirin-exacerbated respiratory disease and urticaria in patients with chronic idiopathic urticaria. Weak inhibitors of COX-1, such as acetaminophen and salsalate, crossreact also but only with high doses of the drugs. Partial inhibitors of both COX-1 and COX-2, such as nimesulide and meloxicam, also cross-react but only at high drug doses. COX-2 inhibitors do not cross-react; however, all NSAIDs, including the selective COX-2 inhibitors, can sensitize patients and induce urticaria or anaphylaxis on next exposure to the drug.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Salsalate	Prostaglandin G/H synthase 1	Protein	Humans	Yes	Inhibitor	Details