Gene structure of human thrombomodulin, a cofactor for thrombin-catalyzed activation of protein C.

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Shirai T, Shiojiri S, Ito H, Yamamoto S, Kusumoto H, Deyashiki Y, Maruyama I, Suzuki K

Gene structure of human thrombomodulin, a cofactor for thrombin-catalyzed activation of protein C.

J Biochem. 1988 Feb;103(2):281-5.

PubMed ID

2836377 [ View in PubMed

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Abstract

The gene coding for human thrombomodulin, a thrombin receptor on endothelial cells and a cofactor for the activation of anticoagulant protein C zymogen, was isolated from a human genomic library by employing human thrombomodulin cDNA as a probe. The nucleotide sequences of the gene and the adjacent 5' and 3' flanking regions were then determined. The nucleotide sequence of this gene with approximately 3.7 kilobase pairs was identical to that of the cDNA, indicating that the gene for human thrombomodulin is free of introns. Hybridization data showed that there is only a single thrombomodulin gene in the human genome.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Drotrecogin alfa	Thrombomodulin	Protein	Humans	Unknown	Not Available	Details

Polypeptides

Name	UniProt ID
Thrombomodulin	P07204	Details