Mutations of the P53 gene, including an intronic point mutation, in colorectal tumors.

Article Details

Citation

Ishioka C, Sato T, Gamoh M, Suzuki T, Shibata H, Kanamaru R, Wakui A, Yamazaki T

Mutations of the P53 gene, including an intronic point mutation, in colorectal tumors.

Biochem Biophys Res Commun. 1991 Jun 28;177(3):901-6.

PubMed ID
1647768 [ View in PubMed
]
Abstract

In this study, analysis of structural changes of the p53 gene in colorectal tumors revealed point mutations detected in 8 of 14 carcinomas and 2 of 2 adenomas. Of these 10 cases with point mutations, eight had one or more missense mutations, one had a nonsense mutation, and the remaining one had, interestingly, an intronic point mutation with subsequent activation of a cryptic splice donor site in the flanking exon. This report contains the first identification of an intronic point mutation of the p53 gene in a colorectal cancer case.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Cellular tumor antigen p53P04637Details