Coupling of human circadian and cell cycles by the timeless protein.

Article Details

Citation

Unsal-Kacmaz K, Mullen TE, Kaufmann WK, Sancar A

Coupling of human circadian and cell cycles by the timeless protein.

Mol Cell Biol. 2005 Apr;25(8):3109-16.

PubMed ID
15798197 [ View in PubMed
]
Abstract

The Timeless protein is essential for circadian rhythm in Drosophila. The Timeless orthologue in mice is essential for viability and appears to be required for the maintenance of a robust circadian rhythm as well. We have found that the human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Serine/threonine-protein kinase Chk1O14757Details