Hemorrhagic stroke associated with the Iowa amyloid precursor protein mutation.
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Greenberg SM, Shin Y, Grabowski TJ, Cooper GE, Rebeck GW, Iglesias S, Chapon F, Tournier-Lasserve E, Baron JC
Hemorrhagic stroke associated with the Iowa amyloid precursor protein mutation.
Neurology. 2003 Mar 25;60(6):1020-2.
- PubMed ID
- 12654973 [ View in PubMed]
- Abstract
The authors searched for mutations in the beta-amyloid precursor protein in a Spanish family with a hereditary syndrome of hemorrhagic stroke, dementia, leukoencephalopathy, and occipital calcifications. DNA from two affected members demonstrated the Iowa amyloid precursor protein mutation previously identified as a cause of severe amyloid angiopathy without hemorrhagic stroke. These data point to other genetic or environmental factors that may determine the occurrence of symptomatic hemorrhage in amyloid angiopathy.