The tricyclic antidepressant clomipramine increases plasma glucose levels of mice.
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Sugimoto Y, Inoue K, Yamada J
The tricyclic antidepressant clomipramine increases plasma glucose levels of mice.
J Pharmacol Sci. 2003 Sep;93(1):74-9.
- PubMed ID
- 14501155 [ View in PubMed]
- Abstract
Effects of the tricyclic antidepressant clomipramine on plasma glucose levels in mice were studied. Clomipramine at doses ranging 5 - 20 mg/kg elicited significant hyperglycemia in mice. Hyperglycemia elicited by clomipramine was not reduced by pretreatment with the 5-hydroxytryptamine (5-HT) depleter p-chlorophenylalanine. The 5-HT(1/2/5/7)-receptor antagonist methysergide and the 5-HT(2A/2B/2C)-receptor antagonist LY 53857 enhanced clomipramine-induced hyperglycemia, while the 5-HT(1A/1B)-receptor antagonist (-)-propranolol and the 5-HT(3/4)-receptor antagonist tropisetron did not affect it. The 5-HT(2B/2C)-receptor antagonist SB 206553 facilitated hyperglycemia induced by clomipramine, although the 5-HT(2A)-receptor antagonist ketanserin was without effect. Clomipramine-induced hyperglycemia was reduced by prior adrenalectomy. These results suggest that clomipramine induces hyperglycemia in mice by blocking the 5-HT(2B )and/or 5-HT(2C) receptors, which results in facilitation of adrenaline release.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Clomipramine 5-hydroxytryptamine receptor 2A Protein Humans YesAntagonistDetails Clomipramine 5-hydroxytryptamine receptor 2B Protein Humans YesAntagonistDetails Clomipramine 5-hydroxytryptamine receptor 2C Protein Humans YesAntagonistDetails Methysergide 5-hydroxytryptamine receptor 1A Protein Humans YesAgonistDetails Methysergide 5-hydroxytryptamine receptor 7 Protein Humans YesAntagonistDetails - Drug Interactions
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interactions in your softwareAcarboseProtriptyline Protriptyline may decrease the hypoglycemic activities of Acarbose. AcarboseNortriptyline Nortriptyline may decrease the hypoglycemic activities of Acarbose. AcarboseAmoxapine Amoxapine may decrease the hypoglycemic activities of Acarbose. AcarboseTrimipramine Trimipramine may decrease the hypoglycemic activities of Acarbose. AcarboseAmineptine Amineptine may decrease the hypoglycemic activities of Acarbose.