An antagonist decoy receptor and a death domain-containing receptor for TRAIL.

Article Details

Citation

Pan G, Ni J, Wei YF, Yu G, Gentz R, Dixit VM

An antagonist decoy receptor and a death domain-containing receptor for TRAIL.

Science. 1997 Aug 8;277(5327):815-8.

PubMed ID
9242610 [ View in PubMed
]
Abstract

TRAIL, also called Apo2L, is a cytotoxic protein that induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types. An antagonist decoy receptor (designated as TRID for TRAIL receptor without an intracellular domain) that may explain the resistant phenotype of normal tissues was identified. TRID is a distinct gene product with an extracellular TRAIL-binding domain and a transmembrane domain but no intracellular signaling domain. TRID transcripts were detected in many normal human tissues but not in most cancer cell lines examined. Ectopic expression of TRID protected mammalian cells from TRAIL-induced apoptosis, which is consistent with a protective role. Another death domain-containing receptor for TRAIL (designated as death receptor-5), which preferentially engaged a FLICE (caspase-8)-related death protease, was also identified.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Tumor necrosis factor receptor superfamily member 10BO14763Details