Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.

Article Details

Citation

Sheridan JP, Marsters SA, Pitti RM, Gurney A, Skubatch M, Baldwin D, Ramakrishnan L, Gray CL, Baker K, Wood WI, Goddard AD, Godowski P, Ashkenazi A

Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.

Science. 1997 Aug 8;277(5327):818-21.

PubMed ID
9242611 [ View in PubMed
]
Abstract

TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional TRAIL receptors were identified. The receptor designated death receptor 5 (DR5) contained a cytoplasmic death domain and induced apoptosis much like DR4. The receptor designated decoy receptor 1 (DcR1) displayed properties of a glycophospholipid-anchored cell surface protein. DcR1 acted as a decoy receptor that inhibited TRAIL signaling. Thus, a cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Tumor necrosis factor receptor superfamily member 10BO14763Details