[Severe erythrodermic psoriasis in a patient with 22q11 deletion syndrome].

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Preiss JC, Zouboulis CC, Zeitz M, Duchmann R

[Severe erythrodermic psoriasis in a patient with 22q11 deletion syndrome].

Med Klin (Munich). 2005 May 13;100(5):275-8.

PubMed ID

15902381 [ View in PubMed

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Abstract

BACKGROUND: Erythrodermic psoriasis is a severe manifestation of psoriasis and can be triggered by several factors. CASE REPORT: A 35-year-old man was admitted with severe, almost generalized exfoliative, oozing erythrodermic psoriasis, fever, and cramping of hands and legs. He was under systemic treatment with acitretin. Laboratory examination revealed a marked hypocalcemia as a consequence of primary hypopara thyroidism as well as hypalbuminemia. After normalization of the serum calcium and albumin levels, cutaneous symptoms and fever rapidly improved. No infectious etiology could be found. Hypoparathyroidism together with a right-sided aorta was caused by a 22q11 deletion syndrome. CONCLUSION: Epidermal cell proliferation and formation of intercellular junctional components of the epidermis are strongly calcium-dependent. Furthermore, carriers like albumin are necessary for the transportation of acitretin in the peripheral tissue. This case report suggests that calcium can be involved in psoriasis pathogenesis at least in a subgroup of patients and that systemic retinoids exhibit insufficient effectiveness under low serum albumin levels.

DrugBank Data that Cites this Article

Drug Carriers

Drug	Carrier	Kind	Organism	Pharmacological Action	Actions
Acitretin	Serum albumin	Protein	Humans	Unknown	Not Available	Details