Variant apolipoprotein AI as a major constituent of a human hereditary amyloid.
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Nichols WC, Dwulet FE, Liepnieks J, Benson MD
Variant apolipoprotein AI as a major constituent of a human hereditary amyloid.
Biochem Biophys Res Commun. 1988 Oct 31;156(2):762-8.
- PubMed ID
- 3142462 [ View in PubMed]
- Abstract
Amyloid fibrils were isolated from spleen and liver of a patient who died with Familial Amyloidotic Polyneuropathy Type III (Iowa). The major protein constituent of the fibrils was found to be the amino terminal portion (residues 1-83) of apolipoprotein AI with an arginine for glycine substitution at position 26. This is the first report of an apolipoprotein as a major amyloid constituent in a form of autosomal dominant hereditary amyloidosis in humans.