Structure of complement receptor 2 in complex with its C3d ligand.

Article Details

Citation

Szakonyi G, Guthridge JM, Li D, Young K, Holers VM, Chen XS

Structure of complement receptor 2 in complex with its C3d ligand.

Science. 2001 Jun 1;292(5522):1725-8.

PubMed ID
11387479 [ View in PubMed
]
Abstract

Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B lymphocyte activation by bridging the innate and adaptive immune systems. CR2 ligands include complement C3d and Epstein-Barr virus glycoprotein 350/220. We describe the x-ray structure of this CR2 domain in complex with C3d at 2.0 angstroms. The structure reveals extensive main chain interactions between C3d and only one short consensus repeat (SCR) of CR2 and substantial SCR side-side packing. These results provide a detailed understanding of receptor-ligand interactions in this protein family and reveal potential target sites for molecular drug design.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Complement C3P01024Details