Perinuclear localisation of cellular retinoic acid binding protein I mRNA.

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Levadoux-Martin M, Li Y, Blackburn A, Chabanon H, Hesketh JE

Perinuclear localisation of cellular retinoic acid binding protein I mRNA.

Biochem Biophys Res Commun. 2006 Feb 3;340(1):326-31.

PubMed ID

16376305 [ View in PubMed

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Abstract

Retinoids are important metabolic and developmental regulators that act through nuclear receptors. The cellular retinoic acid binding protein CRABPI has been suggested to play a role in trafficking of retinoic acid but its exact functions and subcellular localisation remain unclear. Here we show that in CHO cells both exogenous CRABPI transcripts and tagged CRABPI protein have a perinuclear distribution that depends upon the 3'UTR of the mRNA. The CRABPI 3'UTR conferred perinuclear localisation on globin reporter transcripts. Deletion analysis indicated that the first 123nt of CRABPI 3'UTR are necessary for localisation of both CRABPI mRNA and protein. We propose that CRABPI mRNA is localised by a signal within its 3'UTR and that this partly determines the distribution of CRABPI protein.

DrugBank Data that Cites this Article

Drug Carriers

Drug	Carrier	Kind	Organism	Pharmacological Action	Actions
Alitretinoin	Cellular retinoic acid-binding protein 1	Protein	Humans	Unknown	Agonist	Details