Drug binding properties of neonatal albumin.

Article Details

Citation
Copy to clipboard

Brodersen R, Honore B

Drug binding properties of neonatal albumin.

Acta Paediatr Scand. 1989 May;78(3):342-6.

PubMed ID
2545072 [ View in PubMed
]
Abstract

Neonatal and adult albumin was isolated by gel chromatography on Sephacryl S-300, from adult and umbilical cord serum, respectively. Binding of monoacetyl-diamino-diphenyl sulfone, warfarin, sulfamethizole, and diazepam was studied by means of equilibrium dialysis and the binding data were analyzed by the method of several acceptable fitted curves. It was found that the binding affinity to neonatal albumin is less than to adult albumin for monoacetyl-diamino-diphenyl sulfone and warfarin. Sulfamethizole binding to the neonatal protein is similarly reduced when more than one molecule of the drug is bound per albumin molecule, and binding of the first sulfamethizole molecule is possibly reduced as well. Diazepam binds with equal affinity to the fetal and adult proteins. Among the two main albumin drug-binding functions, for warfarin and diazepam, the former is thus compromised in the newborn infant while the diazepam binding function is at the adult level.

DrugBank Data that Cites this Article

Drug Carriers
DrugCarrierKindOrganismPharmacological ActionActions
DiazepamSerum albuminProteinHumans
No
Not AvailableDetails
KetazolamSerum albuminProteinHumans
Unknown
Not AvailableDetails
SulfamethizoleSerum albuminProteinHumans
Unknown
Not AvailableDetails