Fluticasone propionate: safety profile.

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Johnson M

Fluticasone propionate: safety profile.

Cutis. 1996 Feb;57(2 Suppl):10-2.

PubMed ID

8646863 [ View in PubMed

]

Abstract

Fluticasone propionate is a potent fluorinated corticosteroid used for the topical therapy of dermatoses and as inhalation therapy for bronchial asthma and allergic rhinitis. This agent has a good safety profile with a low propensity for systemic side effects, such as suppression of the hypothalamic-pituitary-adrenal (HPA) axis, and a low incidence of local side effects such as pruritus, burning, or skin atrophy. The pharmacologic properties of fluticasone propionate-including high lipophilicity, high selectivity and affinity for the glucocorticoid receptor, low systemic absorption, and rapid metabolism and clearance-combine to give fluticasone propionate a high therapeutic index.

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Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Fluticasone propionate	Glucocorticoid receptor	Protein	Humans	Yes	Agonist	Details