Effects of different phosphodiesterase-inhibiting drugs on human pregnant myometrium: an in vitro study.

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Berg G, Andersson RG, Ryden G

Effects of different phosphodiesterase-inhibiting drugs on human pregnant myometrium: an in vitro study.

Arch Int Pharmacodyn Ther. 1987 Dec;290(2):288-92.

PubMed ID

3446047 [ View in PubMed

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Abstract

The phosphodiesterase (PDE)-inhibiting and smooth muscle relaxing effects of theophylline, enprofylline, papaverine and moxaverine have been studied in vitro on spontaneous contracting human, pregnant myometrium. All drugs showed a close correlation between the PDE-inhibiting and smooth muscle relaxing effect. The order of smooth muscle relaxing potency was papaverine greater than moxaverine greater than enprofylline greater than theophylline. The most potent PDE-inhibitors were moxaverine and papaverine with a 50% PDE-inhibiting concentration (IC50) of 3.3 and 3.8 microM as compared to the least potent PDE-inhibitor, theophylline, with an IC50 of 665 microM. It is concluded that PDE-inhibiting drugs show a close correlation between PDE-inhibiting and relaxing effect on spontaneously contracting pregnant myometrium and that the newly developed drug enprofylline might be of interest in the treatment of premature uterine contractions.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Enprofylline	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	Protein	Humans	Yes	Inhibitor	Details