ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.

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Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, Earley TJ, Hergarden AC, Andersson DA, Hwang SW, McIntyre P, Jegla T, Bevan S, Patapoutian A

ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.

Cell. 2003 Mar 21;112(6):819-29.

PubMed ID

12654248 [ View in PubMed

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Abstract

Mammals detect temperature with specialized neurons in the peripheral nervous system. Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class channel in sensing cold. The combined range of temperatures that activate these channels covers a majority of the relevant physiological spectrum sensed by most mammals, with a significant gap in the noxious cold range. Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8. ANKTM1 is a distant family member of TRP channels with very little amino acid similarity to TRPM8. It is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM8. Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Levomenthol	Transient receptor potential cation channel subfamily A member 1	Protein	Humans	Yes	Inducer	Details
Levomenthol	Transient receptor potential cation channel subfamily M member 8	Protein	Humans	Yes	Inducer	Details