Stereoselective effect of phenprocoumon enantiomers on the binding of benzodiazepines to human serum albumin.

Article Details

Citation

Copy to clipboard

Fitos I, Simonyi M

Stereoselective effect of phenprocoumon enantiomers on the binding of benzodiazepines to human serum albumin.

Chirality. 1992;4(1):21-3.

PubMed ID

1642965 [ View in PubMed

]

Abstract

The effect of phenprocoumon enantiomers on the stereoselective binding of 3-substituted 1,4-benzodiazepines to human serum albumin (HSA) was studied by chromatography on HSA-Sepharose column. (S)-Phenprocoumon exerts stereoselective allosteric interaction on the binding of benzodiazepines. The structural requirements of enhanced stereoselectivities are similar to those found previously with (S)-warfarin.

DrugBank Data that Cites this Article

Drug Carriers

Drug	Carrier	Kind	Organism	Pharmacological Action	Actions
Phenprocoumon	Serum albumin	Protein	Humans	No	Binder Regulator	Details