Maturation of neuromuscular transmission during early development in zebrafish.

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Nguyen PV, Aniksztejn L, Catarsi S, Drapeau P

Maturation of neuromuscular transmission during early development in zebrafish.

J Neurophysiol. 1999 Jun;81(6):2852-61.

PubMed ID

10368402 [ View in PubMed

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Abstract

We have examined the rapid development of synaptic transmission at the neuromuscular junction (NMJ) in zebrafish embryos and larvae by patch-clamp recording of spontaneous miniature endplate currents (mEPCs) and single acetylcholine receptor (AChR) channels. Embryonic (24-36 h) mEPCs recorded in vivo were small in amplitude (<50 pA). The rate of mEPCs increased in larvae (3.5-fold increase measured by 6 days), and these mEPCs were mostly of larger amplitude (10-fold on average) with (

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Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Physostigmine	Acetylcholinesterase	Protein	Humans	Yes	Inhibitor	Details