Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2.
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Kim LA, Furst J, Butler MH, Xu S, Grigorieff N, Goldstein SA
Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2.
J Biol Chem. 2004 Feb 13;279(7):5549-54. Epub 2003 Nov 17.
- PubMed ID
- 14623880 [ View in PubMed]
- Abstract
Mammalian voltage-gated K+ channels are assemblies of pore-forming alpha-subunits and modulating beta-subunits. To operate correctly, Kv4 alpha-subunits in the heart and central nervous system require recently identified beta-subunits of the neuronal calcium sensing protein family called K+ channel-interacting proteins (KChIPs). Here, Kv4.2.KChIP2 channels are purified, integrity of isolated complexes confirmed, molar ratio of the subunits determined, and subunit valence established. A complex has 4 subunits of each type, a stoichiometry expected for other channels employing neuronal calcium sensing beta-subunits.