Sequence and characterization of a coactivator for the steroid hormone receptor superfamily.

Article Details

Citation

Onate SA, Tsai SY, Tsai MJ, O'Malley BW

Sequence and characterization of a coactivator for the steroid hormone receptor superfamily.

Science. 1995 Nov 24;270(5240):1354-7.

PubMed ID
7481822 [ View in PubMed
]
Abstract

A yeast two-hybrid system was used to identify a protein that interacts with and enhances the human progesterone receptor (hPR) transcriptional activity without altering the basal activity of the promoter. Because the protein stimulated transactivation of all the steroid receptors tested, it has been termed steroid receptor coactivator-1 (SRC-1). Coexpression of SRC-1 reversed the ability of the estrogen receptor to squelch activation by hPR. Also, the amino terminal truncated form of SRC-1 acted as a dominant-negative repressor. Together, these results indicate that SRC-1 encodes a coactivator that is required for full transcriptional activity of the steroid receptor superfamily.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Nuclear receptor coactivator 1Q15788Details