Amino acid sequence analysis of human S100A7 (psoriasin) by tandem mass spectrometry.
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Burgisser DM, Siegenthaler G, Kuster T, Hellman U, Hunziker P, Birchler N, Heizmann CW
Amino acid sequence analysis of human S100A7 (psoriasin) by tandem mass spectrometry.
Biochem Biophys Res Commun. 1995 Dec 5;217(1):257-63.
- PubMed ID
- 8526920 [ View in PubMed]
- Abstract
The Ca(2+)-binding proteins regulate a number of cellular and extracellular activities and deregulations of S100 gene expression are associated with several human diseases. For example, S100A7 is upregulated in psoriatic skin, implicating a link with psoriasis, a chronic inflammatory dermatosis. We purified human S100A7 and determined its protein sequence by tandem mass spectrometry and Edman microsequence analysis. Interestingly, a sequence comparison of S100A7 with all known human S100 proteins showed that S100A7 is the most divergent of all S100 proteins.