TGFBR1*6A is not associated with prostate cancer in men of European ancestry.

Article Details

Citation

Suarez BK, Pal P, Jin CH, Kaushal R, Sun G, Jin L, Pasche B, Deka R, Catalona WJ

TGFBR1*6A is not associated with prostate cancer in men of European ancestry.

Prostate Cancer Prostatic Dis. 2005;8(1):50-3.

PubMed ID
15505640 [ View in PubMed
]
Abstract

The TGFBR1*6A (*6A) variant in exon 1 of the TGFBR1 gene has been postulated as a putative tumor susceptibility allele in several studies. We have performed a case-control study in 537 men with histologically verified prostate cancer and in 488 unrelated controls to investigate the association of *6A with prostate cancer. Our results revealed that the frequency of the (*)6A allele does not differ in men with prostate cancer compared to healthy controls, even in a subset of age-matched cases and controls. There is no compelling evidence for an association of the *6A variant with prostate cancer.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
TGF-beta receptor type-1P36897Details