Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms.

Article Details

Citation

Derijard B, Raingeaud J, Barrett T, Wu IH, Han J, Ulevitch RJ, Davis RJ

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms.

Science. 1995 Feb 3;267(5198):682-5.

PubMed ID
7839144 [ View in PubMed
]
Abstract

Mammalian mitogen-activated protein (MAP) kinases include extracellular signal-regulated protein kinase (ERK), c-Jun amino-terminal kinase (JNK), and p38 subgroups. These MAP kinase isoforms are activated by dual phosphorylation on threonine and tyrosine. Two human MAP kinase kinases (MKK3 and MKK4) were cloned that phosphorylate and activate p38 MAP kinase. These MKK isoforms did not activate the ERK subgroup of MAP kinases, but MKK4 did activate JNK. These data demonstrate that the activators of p38 (MKK3 and MKK4), JNK (MKK4), and ERK (MEK1 and MEK2) define independent MAP kinase signal transduction pathways.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Mitogen-activated protein kinase 8P45983Details
Dual specificity mitogen-activated protein kinase kinase 3P46734Details
Dual specificity mitogen-activated protein kinase kinase 4P45985Details