Psychopharmacology of anticonvulsants: levetiracetam as a synaptic vesicle protein modulator.

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Stahl SM

Psychopharmacology of anticonvulsants: levetiracetam as a synaptic vesicle protein modulator.

J Clin Psychiatry. 2004 Sep;65(9):1162-3.

PubMed ID

15367040 [ View in PubMed

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Abstract

ISSUE: A novel mechanism of action has recently been described for levetiracetam, a member of a new class of anticonvulsants. Levetiracetam binds selectively and with high affinity to a synaptic vesicle protein known as SV2A, thought to be involved with synaptic vesicle exocytosis and presynaptic neurotransmitter release.

DrugBank Data that Cites this Article

Drugs

Levetiracetam

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Levetiracetam	Synaptic vesicle glycoprotein 2A	Protein	Humans	Yes	Agonist	Details