Clomipramine enhances the cortisol response to 5-HTP: implications for the therapeutic role of 5-HT2 receptors.
Article Details
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Sargent PA, Quested DJ, Cowen PJ
Clomipramine enhances the cortisol response to 5-HTP: implications for the therapeutic role of 5-HT2 receptors.
Psychopharmacology (Berl). 1998 Nov;140(1):120-2.
- PubMed ID
- 9862411 [ View in PubMed]
- Abstract
We measured the cortisol response to the 5-HT precursor, 5-hydroxytryptophan, (5-HTP) in seven patients with major depression before and after 8 weeks treatment with the tricyclic antidepressant, clomipramine. The cortisol response to 5-HTP was significantly increased following clomipramine treatment, suggesting that clomipramine, like selective serotonin re-uptake inhibitors (SSRIs), enhances this 5-HT2 receptor mediated response. Because other tricyclic antidepressants do not increase 5-HTP-mediated cortisol release, it seems unlikely that enhancement of 5-HT2 receptor function is a critical mechanism for antidepressant action. However, facilitation of neurotransmission at 5-HT2 receptors could account for the efficacy of clomipramine and SSRIs in the treatment of obsessive compulsive disorder and also for their liability to cause orgasmic dysfunction.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Clomipramine 5-hydroxytryptamine receptor 2A Protein Humans YesAntagonistDetails Clomipramine 5-hydroxytryptamine receptor 2B Protein Humans YesAntagonistDetails Clomipramine 5-hydroxytryptamine receptor 2C Protein Humans YesAntagonistDetails