Semicarbazide-sensitive amine oxidase: role in the vasculature and vasodilation after in situ inhibition.

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Vidrio H

Semicarbazide-sensitive amine oxidase: role in the vasculature and vasodilation after in situ inhibition.

Auton Autacoid Pharmacol. 2003 Oct-Dec;23(5-6):275-83.

PubMed ID

15255812 [ View in PubMed

]

Abstract

1. The characteristics of semicarbazide-sensitive amine oxidase (SSAO) are reviewed and the unknown physiological or pathological role of this enzyme emphasized. 2. The various mechanisms of action proposed for the vasodilator drug hydralazine are considered. In particular, the inhibitory action on various enzymes, related or not to cardiovascular function, are discussed. 3. Studies linking inhibition of SSAO to hydralazine hypotension are reviewed and a general hypothesis relating both actions is presented. The hypothesis postulates that (a). vascular SSAO is involved in the regulation of vascular tone, and (b). hydralazine vasodilation is the consequence of vascular SSAO inhibition. 4. Evidence supporting these postulates is presented and vascular SSAO inhibition is proposed as a novel mechanism of vasodilation.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Hydralazine	Membrane primary amine oxidase	Protein	Humans	Yes	Inhibitor	Details